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Copyright © 2004 Cascade BioScience, Inc. All rights reserved.

Description Catalog # Vial Size Price (USD)
Anti-Human PTEN (clone 6H2.1) ABM-2052 100 ug $379
Research Applications
Antibody Characteristics
InfoSheet PDF
Western Immunblotting:
1-5 micrograms/ml
5 micrograms
recommended, protocol
human, mouse; others likely
single band specific; detects PTEN at ~60 kDa in total cell lysates
full-length fusion protein; human sequence; epitope in red
Host/Ig Type:
mouse monoclonal IgG
protein A chromatography
Quality Control:
by WB on numerous breast cancer cell lines
Liquid Carrier:
phosphate-bufferd saline
2 years
Immunohistochemical Analysis
Photomicrographs illustrate PTEN non- expressing neoplastic endometrial glands in a background of normal expressing glands and stroma.
About PTEN
Immunoblot Analysis
6H2.1 single band specificity on 7 breast cancer cell lines; one of which is PTEN-null; one of which has a monoallelic PTEN deletion and a missense mutation
Applications References

Ginn-Pease, M.E. and Eng, C., "Increased Nuclear Phosphatase and Tensin Homologue Deleted on Chromosome 10 Is Associated with G0-G1 in MCF-7 Cells" (2003), Cancer Research 63:282-286.
full text

Schondorf, T., Hoopman, M., Eversheim, B., Valter, M.M., Becker, M., Wappenschmidt, B., Gohring, U.-J., Kubler, T., Schmutzler R. K., and Schafer, R. "Expression of the tumor suppressor gene PTEN is not
altered in the progression of ovarian carcinomas and does not correlate with p27Kip1 expression"
(2003) Oncology Reports 10:1717-1722.
full text

Joëlle Dupont, Jean Pierre Renou, Moshe Shani, Lothar Hennighausen, and Derek LeRoith “PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium” J. Clin. Invest. 110:815–825 (2002).
full text

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